NUP35

Across TCGA pan-cancer cohorts, NUP35 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated NUP35 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUP35 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUP35 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

HNSC, CCRCC, and COAD are the cancer types where NUP35 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.776	0.977	.001	50	view →
CCRCC	DFS	Median	All	0.692	0.915	<.001	44	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.904	.025	30	view →
PDAC	OS	Median	II,III,IV	0.249	0.532	.001	23	view →
LSCC	OS	Quartile	All	0.950	0.637	.002	22	view →
LUAD	OS	Tertile	All	0.934	0.789	.018	11	view →
OV	DFS	Quartile	All	1.000	0.779	.041	4	view →
UCEC	OS	Quartile	All	0.903	1.000	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

NUP35–HNSC (OS)

Open the HNSC breakdown →