NUP35

Across TCGA patient cohorts, NUP35 mutation is significantly associated with the RNA expression of many other genes, with 866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP35-associated genes across cancer lineages are RN7SKP286, GK2, and ARF4P1. Each is linked with NUP35 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP35-to-partner and partner-to-NUP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by NUP35-low versus NUP35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP35→partner) and Y-score (partner→NUP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP286 →	+0.042	+3.890	<.001	.007	3	2
BLCA	GK2 →	+0.030	+5.788	.006	.003	3	2
UCEC	ARF4P1 →	+0.603	+3.669	<.001	.001	3	1
UCEC	CYFIP1 →	+0.621	+2.534	<.001	.001	3	1
UCEC	CASTOR2 →	+0.674	+2.534	.003	.001	3	1
UCEC	LINC02340 →	+0.393	+2.075	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 866 associations by consensus.

RN7SKP286 by NUP35 expression — UCEC

Explore this box plot interactively →