NUP35

Across TCGA patient cohorts, NUP35 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP35-associated genes across cancer lineages are MEK1, ACC_pS79, and p62 Lck ligand. Each is linked with NUP35 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP35-to-partner and partner-to-NUP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NUP35-low versus NUP35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP35→partner) and Y-score (partner→NUP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.395	+3.169	.013	.018	3	2
UCEC	ACC_pS79 →	+0.328	+3.169	.030	.018	3	1
UCEC	p62 Lck ligand →	+0.355	+3.459	.012	.005	3	1
UCEC	AMPK_pT172 →	+0.356	+2.128	.047	.010	3	1
UCEC	Annexin-1 →	+0.681	+2.807	.003	.003	3	1
UCEC	TIGAR →	+0.132	+1.611	.047	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MEK1 by NUP35 expression — UCEC

Explore this box plot interactively →