NUP35

Across TCGA cell cohorts, NUP35 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,010 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NUP35-associated GO terms across cancer lineages are DNA replication initiation, Regulation of DNA damage checkpoint, and Nuclear pore organization. Each is linked with NUP35 in more than 19 cancer types. Because this analysis shows association rather than direction, both NUP35-to-partner and partner-to-NUP35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by NUP35-low versus NUP35-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP35→partner) and Y-score (partner→NUP35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.210	+0.960	.001	.003	3	20
LUNG_NSCLC_LUSC	Regulation of DNA damage checkpoint →	+0.103	+0.888	.005	.008	3	19
LUNG_NSCLC_LUSC	Nuclear pore organization →	+0.155	+0.839	.001	.006	2	19
BLOOD_Myeloma	Immunoglobulin heavy chain V-D-J recombination →	+0.230	+1.098	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Protein localization to kinetochore →	+0.188	+0.994	<.001	.001	3	18
PANCREAS	Spindle elongation →	+0.277	+0.729	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,010 associations by consensus.

DNA replication initiation by NUP35 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →