NUP214

Across TCGA pan-cancer cohorts, NUP214 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUP214 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NUP214 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NUP214 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where NUP214 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.875	0.187	.001	76	view →
PDAC	OS	Median	All	0.419	0.650	<.001	27	view →
HNSC	DFS	Tertile	All	0.269	1.000	.008	16	view →
CCRCC	DFS	Quartile	All	0.573	0.950	.004	12	view →
GBM	OS	Quartile	All	0.610	0.343	.011	8	view →
LSCC	DFS	Tertile	II,III,IV	0.890	0.506	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUP214–LUAD (DFS)

Open the LUAD breakdown →