NUP214

Across TCGA patient cohorts, NUP214 protein abundance is significantly associated with the RNA expression of many other genes, with 16,404 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NUP214-associated genes across cancer lineages are TFB2M, POLR1C, and UTP25. Each is linked with NUP214 in more than 6 cancer types. Because this analysis shows association rather than direction, both NUP214-to-partner and partner-to-NUP214 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NUP214 versus TFB2M in UCEC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP214→partner) and Y-score (partner→NUP214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFB2M →	+0.779	+0.120	<.001	<.001	3	7
LSCC	POLR1C →	+0.510	+0.164	<.001	<.001	3	7
LSCC	UTP25 →	+0.550	+0.178	<.001	<.001	3	6
UCEC	C1orf131 →	+0.573	+0.106	<.001	<.001	3	6
LSCC	LIN9 →	+0.606	+0.201	<.001	<.001	3	6
LSCC	CMSS1 →	+0.571	+0.135	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,404 associations by consensus.

NUP214 vs TFB2M — UCEC

Explore this scatter interactively →