NUP214

Across TCGA patient cohorts, NUP214 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP214-associated genes across cancer lineages are STAT3_pY705, Src_pY527, and Notch1. Each is linked with NUP214 in more than 3 cancer types. Because this analysis shows association rather than direction, both NUP214-to-partner and partner-to-NUP214 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by NUP214-low versus NUP214-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP214→partner) and Y-score (partner→NUP214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.377	-1.836	<.001	<.001	3	4
SKCM	Src_pY527 →	-0.474	-1.874	.003	.047	3	3
UCEC	Notch1 →	+0.149	+1.598	<.001	.002	3	3
COAD	PCNA →	+0.285	+3.008	.026	.019	3	3
UCEC	ATM →	-0.280	-1.401	.022	.040	3	3
UCEC	C-Raf →	+0.113	+1.415	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

STAT3_pY705 by NUP214 expression — UCEC

Explore this box plot interactively →