NUP214

Across TCGA cell cohorts, NUP214 mutation is significantly associated with the RNA expression of many other genes, with 902 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP214-associated genes across cancer lineages are PRSS45P, C12orf57, and KIAA0895. Each is linked with NUP214 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP214-to-partner and partner-to-NUP214 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS45P grouped by NUP214-low versus NUP214-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP214→partner) and Y-score (partner→NUP214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRSS45P →	+0.206	+4.930	<.001	.008	3	2
BLOOD_Leukemia	C12orf57 →	+1.057	+3.351	.003	.003	3	2
BLOOD_Leukemia	KIAA0895 →	+0.870	+3.351	<.001	.003	3	2
BLOOD_Leukemia	TLE2 →	+1.670	+3.351	<.001	.003	3	2
BLOOD_Lymphoma	CFAP97D1 →	+0.027	+3.736	<.001	.009	3	2
LARGE_INTESTINE	ULBP1 →	+0.997	+2.364	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 902 associations by consensus.

PRSS45P by NUP214 expression — SOFT_TISSUE

Explore this box plot interactively →