NUP188

Across TCGA pan-cancer cohorts, NUP188 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NUP188 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NUP188 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NUP188 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where NUP188 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.904	0.429	.002	40	view →
CCRCC	DFS	Median	All	0.719	0.894	.009	26	view →
LSCC	DFS	Tertile	II,III,IV	0.891	0.423	.002	23	view →
PDAC	DFS	Median	All	0.696	0.824	.021	5	view →
HNSC	DFS	Tertile	III,IV	0.663	0.879	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NUP188–LUAD (OS)

Open the LUAD breakdown →