NUP188

Across TCGA patient cohorts, NUP188 mutation is significantly associated with the RNA expression of many other genes, with 4,907 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP188-associated genes across cancer lineages are MCM5, CCNB2, and MRPL54. Each is linked with NUP188 in more than 3 cancer types. Because this analysis shows association rather than direction, both NUP188-to-partner and partner-to-NUP188 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM5 grouped by NUP188-low versus NUP188-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP188→partner) and Y-score (partner→NUP188) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MCM5 →	+0.544	+3.346	.005	.004	3	4
STAD	CCNB2 →	+0.687	+3.334	.004	.005	3	4
STAD	MRPL54 →	+0.532	+3.716	<.001	<.001	3	4
UCEC	NCAPH2 →	+0.586	+2.415	<.001	<.001	3	4
UCEC	ORC1 →	+0.716	+3.480	<.001	<.001	3	4
STAD	NANS →	+0.701	+2.840	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,907 associations by consensus.

MCM5 by NUP188 expression — STAD

Explore this box plot interactively →