NUP188

Across TCGA patient cohorts, NUP188 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP188-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and eEF2. Each is linked with NUP188 in more than 4 cancer types. Because this analysis shows association rather than direction, both NUP188-to-partner and partner-to-NUP188 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NUP188-low versus NUP188-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP188→partner) and Y-score (partner→NUP188) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.642	+2.999	.001	<.001	3	5
STAD	4E-BP1 →	+0.373	+3.000	.011	.034	3	3
STAD	eEF2 →	+0.307	+3.169	.039	.019	1	4
STAD	Src_pY527 →	-0.724	-3.169	.002	.018	3	2
BLCA	GSK3-a-b →	+0.194	+3.459	.004	.005	3	2
BLCA	Bax →	+0.155	+2.584	.048	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by NUP188 expression — UCEC

Explore this box plot interactively →