NUP188

Across TCGA cell cohorts, NUP188 mutation is significantly associated with the mutation status of many other genes, with 4,549 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP188-associated genes across cancer lineages are PCDHB12, VPS13D, and HSPG2. Each is linked with NUP188 in more than 5 cancer types. Because this analysis shows association rather than direction, both NUP188-to-partner and partner-to-NUP188 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDHB12 grouped by NUP188-low versus NUP188-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP188→partner) and Y-score (partner→NUP188) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PCDHB12 →	+1.632	+2.502	.005	.005	1	6
BREAST	VPS13D →	+4.807	+3.857	.002	.002	1	5
BREAST	HSPG2 →	+3.222	+3.222	.009	.009	1	5
BLOOD_Leukemia	DSG4 →	+3.545	+3.083	<.001	<.001	1	5
BLOOD_Lymphoma	ATXN2L →	+3.337	+2.969	.009	.009	1	5
CNS	MCM4 →	+5.277	+4.459	.005	.005	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,549 associations by consensus.

PCDHB12 by NUP188 expression — LARGE_INTESTINE

Explore this box plot interactively →