NUP188

Across TCGA cell cohorts, NUP188 mutation is significantly associated with the drug of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP188-associated genes across cancer lineages are Ipatasertib, RU-SKI 43, and Niraparib. Each is linked with NUP188 in more than 2 cancer types. Because this analysis shows association rather than direction, both NUP188-to-partner and partner-to-NUP188 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ipatasertib grouped by NUP188-low versus NUP188-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP188→partner) and Y-score (partner→NUP188) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Ipatasertib →	+0.372	+2.169	.046	.047	2	3
BLOOD_Leukemia	RU-SKI 43 →	+0.271	+3.360	.034	.003	3	2
LARGE_INTESTINE	Niraparib →	+0.361	+2.646	.042	.047	3	1
LARGE_INTESTINE	Doxorubicin →	+0.744	+2.649	.004	.046	2	2
LARGE_INTESTINE	GSK429286A →	+0.441	+2.652	.003	.045	3	1
LARGE_INTESTINE	GSK690693 →	+0.845	+2.791	<.001	.028	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Ipatasertib by NUP188 expression — BLOOD_Leukemia

Explore this box plot interactively →