NUP160

Across TCGA patient cohorts, NUP160 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP160-associated genes across cancer lineages are TIGAR, p90 RSK, and Notch1. Each is linked with NUP160 in more than 3 cancer types. Because this analysis shows association rather than direction, both NUP160-to-partner and partner-to-NUP160 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by NUP160-low versus NUP160-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP160→partner) and Y-score (partner→NUP160) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TIGAR →	+0.381	+2.853	<.001	.034	3	4
STAD	p90 RSK →	+0.363	+3.169	.001	.018	3	3
UCEC	Notch1 →	+0.193	+2.115	<.001	<.001	3	3
LUSC	JNK2 →	+0.462	+2.834	<.001	.035	3	2
LUSC	Ku80 →	+0.567	+2.834	.002	.035	3	2
LUSC	beta-Catenin →	+0.628	+2.816	.026	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

TIGAR by NUP160 expression — LUSC

Explore this box plot interactively →