NUP155

Across TCGA patient cohorts, NUP155 mutation is significantly associated with the RNA expression of many other genes, with 4,028 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP155-associated genes across cancer lineages are MAD2L1, ALKBH1, and SAP18. Each is linked with NUP155 in more than 3 cancer types. Because this analysis shows association rather than direction, both NUP155-to-partner and partner-to-NUP155 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAD2L1 grouped by NUP155-low versus NUP155-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP155→partner) and Y-score (partner→NUP155) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAD2L1 →	+0.699	+2.906	<.001	.001	3	4
UCEC	ALKBH1 →	+0.340	+2.499	.001	.001	3	4
UCEC	SAP18 →	+0.243	+2.371	.006	.003	3	3
UCEC	OXSM →	+0.368	+4.087	<.001	<.001	3	3
UCEC	EIF4E →	+0.445	+3.103	<.001	<.001	2	4
UCEC	HAUS1 →	+0.555	+3.928	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,028 associations by consensus.

MAD2L1 by NUP155 expression — UCEC

Explore this box plot interactively →