NUP155

Across TCGA patient cohorts, NUP155 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP155-associated genes across cancer lineages are Heregulin, eEF2, and FoxM1. Each is linked with NUP155 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP155-to-partner and partner-to-NUP155 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by NUP155-low versus NUP155-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP155→partner) and Y-score (partner→NUP155) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Heregulin →	+0.230	+3.204	.023	.009	3	2
UCEC	eEF2 →	+0.394	+2.000	.001	.029	3	2
UCEC	FoxM1 →	+0.196	+1.884	.032	.030	3	2
UCEC	JNK_pT183_Y185 →	-0.173	-1.678	.003	.021	3	2
UCEC	mTOR_pS2448 →	-0.119	-1.565	.024	.034	3	2
UCEC	TFRC →	+0.545	+3.459	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Heregulin by NUP155 expression — BLCA

Explore this box plot interactively →