NUP153

Across TCGA pan-cancer cohorts, NUP153 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NUP153’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NUP153 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NUP153 is over-expressed in tumor.

COAD, LSCC, and LUAD are the cancer types where NUP153 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUP153 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.396	<.001	10	view →
LSCC	Male	All	+0.644	<.001	9	view →
LUAD	Male	All	+0.363	<.001	9	view →
HNSC	All	IV	+0.324	<.001	8	view →
CCRCC	Male	III,IV	+0.191	<.001	6	view →
OV	All	All	+0.393	.004	2	view →
PDAC	Female	All	+0.120	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NUP153–COAD

Open the COAD breakdown →