NUP133

Across TCGA pan-cancer cohorts, NUP133 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NUP133 data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUP133 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUP133 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where NUP133 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.510	0.845	.004	21	view →
PDAC	OS	Tertile	All	0.656	0.962	.005	13	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	11	view →
LSCC	DFS	Quartile	II,III,IV	0.804	0.374	.012	7	view →
LUAD	DFS	Median	II,III,IV	0.915	0.796	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NUP133–CCRCC (OS)

Open the CCRCC breakdown →