NUP133

Across TCGA patient cohorts, NUP133 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUP133-associated genes across cancer lineages are p70-S6K, ERK2, and Ku80. Each is linked with NUP133 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP133-to-partner and partner-to-NUP133 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by NUP133-low versus NUP133-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP133→partner) and Y-score (partner→NUP133) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	p70-S6K →	+0.274	+2.828	.028	.033	3	2
UCEC	ERK2 →	+0.150	+1.502	.033	.030	3	2
UCEC	Ku80 →	+0.188	+1.515	.030	.018	3	2
UCEC	AMPK_pT172 →	+0.382	+3.321	.011	.009	3	2
UCEC	Rictor_pT1135 →	-0.124	-2.736	<.001	<.001	3	2
UCEC	ATM →	-0.518	-3.308	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p70-S6K by NUP133 expression — STAD

Explore this box plot interactively →