NUP133

Across TCGA cell cohorts, NUP133 mutation is significantly associated with the drug of many other genes, with 48 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUP133-associated genes across cancer lineages are Nutlin-3a (-), GSK1904529A, and Niraparib. Each is linked with NUP133 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUP133-to-partner and partner-to-NUP133 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nutlin-3a (-) grouped by NUP133-low versus NUP133-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUP133→partner) and Y-score (partner→NUP133) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nutlin-3a (-) →	+0.848	+2.868	.013	.022	3	1
LARGE_INTESTINE	GSK1904529A →	+0.413	+2.678	.008	.037	3	1
LARGE_INTESTINE	Niraparib →	+0.339	+2.868	.044	.022	3	1
LARGE_INTESTINE	123829 →	+0.654	+2.871	.017	.021	3	1
LARGE_INTESTINE	Sabutoclax →	+0.473	+2.991	.017	.018	3	1
LARGE_INTESTINE	TL-2-105 →	+0.576	+2.874	.001	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Nutlin-3a (-) by NUP133 expression — LARGE_INTESTINE

Explore this box plot interactively →