Across TCGA pan-cancer cohorts, NUGGC mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of NUGGC’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where NUGGC mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NUGGC is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where NUGGC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUGGC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.877	<.001	7	view →
LUAD	Male	All	+0.931	<.001	6	view →
CCRCC	All	All	−1.205	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: NUGGC RNA expression & survival · all NUGGC data types