Across TCGA patient cohorts, NUGGC mutation is significantly associated with the RNA expression of many other genes, with 3,590 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUGGC-associated genes across cancer lineages are CDCA2, ASIC3, and FANCC. Each is linked with NUGGC in more than 2 cancer types. Because this analysis shows association rather than direction, both NUGGC-to-partner and partner-to-NUGGC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUGGC→partner) and Y-score (partner→NUGGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA2 →	+0.711	+1.906	<.001	<.001	3	3
COAD	ASIC3 →	+0.637	+3.200	<.001	.009	3	3
UCEC	FANCC →	+0.390	+2.491	<.001	<.001	3	3
UCEC	CHAF1B →	+0.512	+2.408	<.001	<.001	3	3
UCEC	NUDT2 →	+0.449	+2.202	<.001	.001	3	3
UCEC	ZNF367 →	+0.650	+2.146	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,590 associations by consensus.

Exploration

NUGGC survival (RNA) · tumor vs normal (RNA) · all NUGGC data types