NUGGC

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NUGGC mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUGGC-associated genes across cancer lineages are Cyclin-B1, Shc_pY317, and TFRC. Each is linked with NUGGC in more than 2 cancer types. Because this analysis shows association rather than direction, both NUGGC-to-partner and partner-to-NUGGC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUGGC→partner) and Y-score (partner→NUGGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCyclin-B1 →+0.653+3.906<.001<.00133
SKCMShc_pY317 →-0.187-2.567.033.01132
SKCMTFRC →+0.539+2.584.036.01132
UCEC14-3-3_beta →-0.077-2.195.014.00932
UCECEGFR_pY1068 →-0.216-1.584.006.01732
UCECMEK1 →+0.430+2.459<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration