Across TCGA cell cohorts, NUGGC mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUGGC-associated genes across cancer lineages are ARMH2, SMIM28, and CEACAM8. Each is linked with NUGGC in more than 1 cancer types. Because this analysis shows association rather than direction, both NUGGC-to-partner and partner-to-NUGGC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUGGC→partner) and Y-score (partner→NUGGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ARMH2 →	+0.039	+4.228	<.001	.006	3	2
CNS	SMIM28 →	+0.046	+5.321	<.001	.005	3	1
SKIN	CEACAM8 →	+0.009	+3.217	<.001	.006	3	1
SKIN	ODF1 →	+0.011	+3.700	<.001	.009	3	1
SKIN	OR4D11 →	+0.018	+3.700	<.001	.009	3	1
SKIN	FNDC8 →	+0.132	+3.691	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

NUGGC survival (RNA) · tumor vs normal (RNA) · all NUGGC data types