NUFIP2

Across TCGA patient cohorts, NUFIP2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUFIP2-associated genes across cancer lineages are PDCD4, Shc_pY317, and ASNS. Each is linked with NUFIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUFIP2-to-partner and partner-to-NUFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by NUFIP2-low versus NUFIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUFIP2→partner) and Y-score (partner→NUFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.351	-1.415	.016	.010	3	2
UCEC	Shc_pY317 →	-0.177	-1.847	<.001	.007	3	2
UCEC	ASNS →	+0.423	+2.247	<.001	.001	3	2
UCEC	Bak →	+0.177	+1.415	.022	.010	3	2
UCEC	14-3-3_beta →	-0.077	-1.780	.013	.024	3	1
UCEC	eEF2 →	+0.332	+2.700	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

PDCD4 by NUFIP2 expression — UCEC

Explore this box plot interactively →