NUF2

Across TCGA pan-cancer cohorts, NUF2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NUF2 data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUF2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUF2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where NUF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.596	0.834	.001	15	view →
CCRCC	DFS	Quartile	II,III,IV	0.718	1.000	.022	10	view →
LSCC	OS	Quartile	All	1.000	0.758	.013	6	view →
LUAD	OS	Quartile	All	0.232	0.893	.026	6	view →
PDAC	DFS	Quartile	II,III,IV	0.623	0.124	.048	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NUF2–HNSC (OS)

Open the HNSC breakdown →