NUF2

Across TCGA patient cohorts, NUF2 mutation is significantly associated with the RNA expression of many other genes, with 795 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUF2-associated genes across cancer lineages are HIRIP3, SNRNP25, and AKIP1. Each is linked with NUF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUF2-to-partner and partner-to-NUF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIRIP3 grouped by NUF2-low versus NUF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUF2→partner) and Y-score (partner→NUF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIRIP3 →	+0.443	+3.266	.009	.008	3	2
UCEC	SNRNP25 →	+0.463	+4.075	.004	<.001	3	2
UCEC	AKIP1 →	+0.416	+3.483	.007	.002	3	2
UCEC	SAAL1 →	+0.578	+3.332	.001	.005	3	2
UCEC	MRTO4 →	+0.422	+3.332	.004	.005	3	2
UCEC	TIPIN →	+0.505	+2.724	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 795 associations by consensus.

HIRIP3 by NUF2 expression — UCEC

Explore this box plot interactively →