NUF2

Across TCGA cell cohorts, NUF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,651 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NUF2-associated GO terms across cancer lineages are Centrosome duplication, Regulation of G2/M transition of mitotic cell cycle, and Regulation of centrosome duplication. Each is linked with NUF2 in more than 18 cancer types. Because this analysis shows association rather than direction, both NUF2-to-partner and partner-to-NUF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome duplication grouped by NUF2-low versus NUF2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUF2→partner) and Y-score (partner→NUF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Centrosome duplication →	+0.101	+1.333	<.001	.001	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.105	+1.440	<.001	.001	3	19
LUNG_SCLC	Regulation of centrosome duplication →	+0.117	+0.782	<.001	<.001	3	19
OESOPHAGUS	Meiotic chromosome segregation →	+0.199	+1.711	<.001	<.001	3	19
OESOPHAGUS	Chromosome localization →	+0.152	+1.403	<.001	<.001	3	18
STOMACH	Spindle elongation →	+0.255	+1.336	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,651 associations by consensus.

Centrosome duplication by NUF2 expression — UPPER_AERODIGESTIVE_TRACT

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