NUF2

Across TCGA cell cohorts, NUF2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NUF2-associated genes across cancer lineages are KLRF2, FCGR3B, and BPIFB6. Each is linked with NUF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUF2-to-partner and partner-to-NUF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLRF2 grouped by NUF2-low versus NUF2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUF2→partner) and Y-score (partner→NUF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KLRF2 →	+0.193	+4.643	<.001	.008	3	1
LARGE_INTESTINE	FCGR3B →	+0.139	+3.882	<.001	.001	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	HTR1E →	+0.039	+3.345	.009	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
LARGE_INTESTINE	RTP1 →	+0.200	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

KLRF2 by NUF2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →