NUDT7

Across TCGA pan-cancer cohorts, NUDT7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NUDT7’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NUDT7 RNA is repressed in tumor relative to normal tissue. In most cancer types NUDT7 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and BLCA are the cancer types where NUDT7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUDT7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.958	<.001	11	view →
KIRC	Male	II,III,IV	−0.682	<.001	11	view →
BLCA	Male	IV	−1.714	<.001	8	view →
UCEC	All	All	−1.510	<.001	6	view →
BRCA	All	II,III,IV	−1.278	<.001	6	view →
COAD	Female	All	−0.693	<.001	6	view →
LUSC	All	II,III,IV	−0.649	.001	6	view →
KICH	All	All	−0.543	.005	6	view →
LUAD	All	II,III,IV	−0.520	<.001	6	view →
CHOL	Male	All	−0.963	<.001	4	view →
KIRP	Male	All	−0.582	.002	3	view →
READ	All	II,III,IV	−0.905	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NUDT7–THCA

Open the THCA breakdown →