NUDT5

Across TCGA pan-cancer cohorts, NUDT5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUDT5 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NUDT5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUDT5 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, COAD, and GBM are the cancer types where NUDT5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.285	0.795	.003	10	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
GBM	OS	Median	All	0.441	0.626	.025	6	view →
HNSC	OS	Median	All	1.000	0.497	.046	4	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
CCRCC	DFS	Quartile	All	0.633	0.904	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUDT5–LUAD (DFS)

Open the LUAD breakdown →