NUDT5

Across TCGA patient cohorts, NUDT5 mutation is significantly associated with the RNA expression of many other genes, with 929 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT5-associated genes across cancer lineages are RNU6-649P, MIR944, and MIR5186. Each is linked with NUDT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT5-to-partner and partner-to-NUDT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-649P grouped by NUDT5-low versus NUDT5-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT5→partner) and Y-score (partner→NUDT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	RNU6-649P →	+0.568	+7.962	<.001	.007	3	1
THCA	MIR944 →	+0.394	+7.962	<.001	.007	3	1
THCA	MIR5186 →	+0.337	+7.962	<.001	.007	3	1
THCA	MIR3910-1 →	+0.328	+7.962	<.001	.007	3	1
COAD	RNF14P2 →	+0.277	+7.741	<.001	.009	3	1
COAD	RNU4ATAC9P →	+0.322	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 929 associations by consensus.

RNU6-649P by NUDT5 expression — THCA

Explore this box plot interactively →