NUDT3

Across TCGA patient cohorts, NUDT3 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. COAD shows the largest number of these associations.

The most reproducible NUDT3-associated genes across cancer lineages are RN7SKP265, MTATP6P14, and FGF21. Each is linked with NUDT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT3-to-partner and partner-to-NUDT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP265 grouped by NUDT3-low versus NUDT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT3→partner) and Y-score (partner→NUDT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP265 →	+0.213	+4.464	<.001	.005	3	2
SKCM	MTATP6P14 →	+0.052	+5.469	<.001	.002	3	2
UCEC	FGF21 →	+0.508	+3.791	.004	.002	3	1
UCEC	IL21 →	+0.224	+2.763	<.001	.009	3	1
SKCM	MRPL57P7 →	+0.125	+5.469	<.001	.002	3	1
SKCM	AGGF1P5 →	+0.045	+5.624	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

RN7SKP265 by NUDT3 expression — UCEC

Explore this box plot interactively →