NUDT3

Across TCGA cell cohorts, NUDT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,954 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NUDT3-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Positive regulation of gene expression, epigenetic, and Epigenetic regulation of gene expression. Each is linked with NUDT3 in more than 14 cancer types. Because this analysis shows association rather than direction, both NUDT3-to-partner and partner-to-NUDT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by NUDT3-low versus NUDT3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT3→partner) and Y-score (partner→NUDT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Subtelomeric heterochromatin formation →	+0.146	+1.029	<.001	<.001	3	14
BONE	Positive regulation of gene expression, epigenetic →	+0.088	+0.852	.001	.006	3	14
BONE	Epigenetic regulation of gene expression →	+0.096	+1.061	<.001	.001	3	14
BONE	Nucleosome disassembly →	+0.226	+1.203	<.001	<.001	3	14
BONE	Internal protein amino acid acetylation →	+0.223	+1.120	<.001	<.001	3	14
BONE	Negative regulation of RNA export from nucleus →	+0.148	+0.936	.005	.005	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,954 associations by consensus.

Subtelomeric heterochromatin formation by NUDT3 expression — LARGE_INTESTINE

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