NUDT22

Across TCGA patient cohorts, NUDT22 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT22-associated genes across cancer lineages are Ku80, TFRC, and Bak. Each is linked with NUDT22 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT22-to-partner and partner-to-NUDT22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by NUDT22-low versus NUDT22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT22→partner) and Y-score (partner→NUDT22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.290	+3.472	.014	.002	3	1
UCEC	TFRC →	+0.720	+2.321	.006	.035	3	1
UCEC	Bak →	+0.265	+2.321	.035	.035	3	1
UCEC	BRD4 →	+0.322	+2.818	.016	.035	3	1
UCEC	C-Raf →	+0.277	+2.321	<.001	.034	3	1
UCEC	A-Raf_pS299 →	-0.192	-3.000	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by NUDT22 expression — UCEC

Explore this box plot interactively →