NUDT21

Across TCGA pan-cancer cohorts, NUDT21 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NUDT21 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUDT21 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUDT21 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

HNSC, COAD, and UCEC are the cancer types where NUDT21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.826	0.967	.001	27	view →
COAD	DFS	Median	II,III,IV	1.000	0.885	.026	12	view →
UCEC	OS	Tertile	II,III,IV	0.626	1.000	.036	8	view →
CCRCC	OS	Median	All	0.909	1.000	.019	6	view →
LSCC	DFS	Quartile	II,III,IV	0.765	0.186	.024	3	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
PDAC	OS	Tertile	III,IV	1.000	0.571	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NUDT21–HNSC (OS)

Open the HNSC breakdown →