NUDT2

Across TCGA patient cohorts, NUDT2 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NUDT2-associated genes across cancer lineages are ARHGAP42P3, GYG1P2, and MTCO3P17. Each is linked with NUDT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT2-to-partner and partner-to-NUDT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP42P3 grouped by NUDT2-low versus NUDT2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT2→partner) and Y-score (partner→NUDT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ARHGAP42P3 →	+0.022	+6.624	<.001	.001	3	1
SKCM	GYG1P2 →	+0.084	+5.037	<.001	.009	3	1
SKCM	MTCO3P17 →	+0.104	+5.436	<.001	.005	3	1
SKCM	RN7SL677P →	+0.237	+5.362	<.001	.005	3	1
UCEC	MIR4665 →	+1.077	+4.211	<.001	.009	3	1
UCEC	MIR3135A →	+0.990	+5.038	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ARHGAP42P3 by NUDT2 expression — SKCM

Explore this box plot interactively →