NUDT15

Across TCGA pan-cancer cohorts, NUDT15 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NUDT15 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUDT15 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NUDT15 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, GBM, and LSCC are the cancer types where NUDT15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.985	0.144	.008	10	view →
GBM	OS	Tertile	All	0.610	0.895	.021	3	view →
LSCC	DFS	Median	All	0.844	0.632	.027	1	view →
HNSC	DFS	Median	III,IV	0.911	0.992	.039	1	view →
PDAC	DFS	Quartile	III,IV	0.483	0.789	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NUDT15–CCRCC (DFS)

Open the CCRCC breakdown →