NUDT15

Across TCGA pan-cancer cohorts, NUDT15 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NUDT15’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where NUDT15 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NUDT15 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

PDAC, COAD, and CCRCC are the cancer types where NUDT15 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NUDT15 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+0.285	.010	2	view →
COAD	Female	All	+0.255	.003	2	view →
CCRCC	Male	All	+0.161	.011	2	view →
HNSC	Male	All	−0.151	.021	2	view →
LSCC	Female	All	−0.216	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

NUDT15–PDAC

Open the PDAC breakdown →