NUDT15

Across TCGA patient cohorts, NUDT15 protein abundance is significantly associated with the RNA expression of many other genes, with 8,823 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NUDT15-associated genes across cancer lineages are SUCLA2, EXOSC8, and POLR1D. Each is linked with NUDT15 in more than 7 cancer types. Because this analysis shows association rather than direction, both NUDT15-to-partner and partner-to-NUDT15 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NUDT15 versus SUCLA2 in LSCC, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT15→partner) and Y-score (partner→NUDT15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUCLA2 →	+0.582	+0.413	<.001	<.001	3	8
LSCC	EXOSC8 →	+0.439	+0.293	<.001	<.001	3	6
CCRCC	POLR1D →	+0.348	+0.414	<.001	.001	3	6
GBM	MED4 →	+0.603	+0.587	<.001	<.001	3	6
LSCC	WBP4 →	+0.455	+0.341	<.001	<.001	3	6
GBM	MRPS31 →	+0.359	+0.426	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,823 associations by consensus.

NUDT15 vs SUCLA2 — LSCC

Explore this scatter interactively →