NUDT15

Across TCGA cell cohorts, NUDT15 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,055 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NUDT15-associated GO terms across cancer lineages are DNA protection, Establishment of meiotic spindle orientation, and Positive regulation of chromosome separation. Each is linked with NUDT15 in more than 17 cancer types. Because this analysis shows association rather than direction, both NUDT15-to-partner and partner-to-NUDT15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA protection grouped by NUDT15-low versus NUDT15-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT15→partner) and Y-score (partner→NUDT15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA protection →	+0.176	+0.793	<.001	<.001	3	18
BLOOD_Myeloma	Establishment of meiotic spindle orientation →	+0.162	+0.948	.003	.002	3	17
SOFT_TISSUE	Positive regulation of chromosome separation →	+0.178	+0.846	<.001	<.001	3	16
BONE	Positive regulation of mitotic metaphase/anaphase transition →	+0.201	+1.206	<.001	<.001	3	16
OESOPHAGUS	Chromosome localization →	+0.143	+1.219	.002	.001	3	16
OESOPHAGUS	Mitotic metaphase chromosome alignment →	+0.144	+1.198	.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,055 associations by consensus.

DNA protection by NUDT15 expression — PANCREAS

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