Across TCGA pan-cancer cohorts, NUDT14 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NUDT14 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NUDT14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUDT14 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where NUDT14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.286	0.917	.006	31	view →
CCRCC	DFS	Tertile	III,IV	0.904	0.125	.024	20	view →
LSCC	DFS	Tertile	III,IV	1.000	0.446	.007	13	view →
LUAD	DFS	Median	All	0.825	0.657	.009	13	view →
PDAC	DFS	Median	All	0.836	0.705	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: NUDT14 tumor-vs-normal RNA expression · all NUDT14 data types