NUDT12

Across TCGA pan-cancer cohorts, NUDT12 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NUDT12 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher NUDT12 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NUDT12 expression acts as an unfavorable survival marker.

LUSC, COAD, and HNSC are the cancer types where NUDT12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.255	0.721	.001	27	view →
COAD	OS	Median	All	0.168	0.806	.002	12	view →
HNSC	OS	Median	All	0.196	0.603	.032	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NUDT12–LUSC (DFS)

Open the LUSC breakdown →