NUDT12

Across TCGA pan-cancer cohorts, NUDT12 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NUDT12 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUDT12 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NUDT12 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and PDAC are the cancer types where NUDT12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	1.000	0.779	.006	26	view →
COAD	DFS	Median	III,IV	1.000	0.886	.026	12	view →
PDAC	OS	Median	All	0.565	0.416	.029	8	view →
HNSC	OS	Tertile	II,III,IV	0.945	0.852	.023	6	view →
LSCC	OS	Tertile	III,IV	0.480	0.853	.044	2	view →
LUAD	DFS	Tertile	II,III,IV	0.767	0.947	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NUDT12–CCRCC (OS)

Open the CCRCC breakdown →