NUDT12

Across TCGA patient cohorts, NUDT12 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT12-associated genes across cancer lineages are FASN, Tuberin, and Bax. Each is linked with NUDT12 in more than 2 cancer types. Because this analysis shows association rather than direction, both NUDT12-to-partner and partner-to-NUDT12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by NUDT12-low versus NUDT12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT12→partner) and Y-score (partner→NUDT12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.612	+2.321	<.001	.034	3	3
UCEC	Tuberin →	+0.366	+3.169	.002	.018	3	2
UCEC	Bax →	+0.257	+3.321	.017	.009	3	2
UCEC	EGFR_pY1068 →	-0.338	-3.459	.002	.005	3	1
UCEC	FoxM1 →	+0.252	+2.700	.031	.006	3	1
UCEC	INPP4B →	-0.347	-3.321	.017	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FASN by NUDT12 expression — UCEC

Explore this box plot interactively →