NUDT10

Across TCGA patient cohorts, NUDT10 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT10-associated genes across cancer lineages are PCNA, EGFR, and FoxM1. Each is linked with NUDT10 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT10-to-partner and partner-to-NUDT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NUDT10-low versus NUDT10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT10→partner) and Y-score (partner→NUDT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.269	+2.115	.004	.019	3	2
UCEC	EGFR →	-0.153	-2.115	.029	.019	3	1
UCEC	FoxM1 →	+0.285	+2.115	.011	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-3.321	.010	.010	3	1
UCEC	JNK2 →	+0.287	+2.115	<.001	.019	3	1
UCEC	MEK1_p_S217_S221 →	-0.236	-3.169	.048	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PCNA by NUDT10 expression — UCEC

Explore this box plot interactively →