NUDT1

Across TCGA pan-cancer cohorts, NUDT1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NUDT1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NUDT1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NUDT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where NUDT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.351	0.839	.001	37	view →
LSCC	DFS	Tertile	II,III,IV	0.936	0.522	.003	22	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.553	.019	8	view →
HNSC	OS	Median	III,IV	0.763	0.548	.030	5	view →
PDAC	OS	Median	IV	0.491	0.836	.024	5	view →
LUAD	OS	Median	All	0.662	0.842	.017	5	view →
OV	DFS	Median	All	0.874	1.000	.043	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NUDT1–CCRCC (OS)

Open the CCRCC breakdown →