NUDT1

Across TCGA patient cohorts, NUDT1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDT1-associated genes across cancer lineages are EGFR_pY1068, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with NUDT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDT1-to-partner and partner-to-NUDT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NUDT1-low versus NUDT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDT1→partner) and Y-score (partner→NUDT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.348	-3.000	.016	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.636	-2.986	.014	.037	3	1
UCEC	PDCD4 →	-1.039	-2.990	<.001	.036	3	1
UCEC	TIGAR →	+0.303	+3.026	<.001	.019	3	1
UCEC	Bax →	+0.323	+2.817	.019	.036	3	1
UCEC	mTOR_pS2448 →	-0.264	-3.000	.002	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EGFR_pY1068 by NUDT1 expression — UCEC

Explore this box plot interactively →