NUDCD2

Across TCGA pan-cancer cohorts, NUDCD2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NUDCD2 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher NUDCD2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NUDCD2 expression acts as an unfavorable survival marker, although some lineages such as READ and MESO show a favorable association.

SCLC, READ, and KIRP are the cancer types where NUDCD2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.428	0.708	<.001	112	view →
READ	DFS	Median	All	0.727	0.350	<.001	92	view →
KIRP	DFS	Tertile	All	0.849	0.965	<.001	88	view →
HNSC	DFS	Tertile	All	0.239	0.441	<.001	81	view →
KICH	OS	Quartile	II,III,IV	0.497	1.000	.002	59	view →
MESO	OS	Median	III,IV	0.794	0.291	.001	57	view →
KIRC	DFS	Tertile	All	0.881	0.674	<.001	40	view →
ESCA	DFS	Tertile	All	0.401	0.656	<.001	32	view →
UVM	DFS	Tertile	III,IV	0.180	1.000	.007	22	view →
LIHC	OS	Quartile	All	0.706	0.881	.004	18	view →
THCA	DFS	Median	IV	0.563	0.984	.001	15	view →
CESC	DFS	Quartile	All	0.790	0.901	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NUDCD2–SCLC (OS)

Open the SCLC breakdown →