NUDCD1

Across TCGA patient cohorts, NUDCD1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NUDCD1-associated genes across cancer lineages are Notch1, VHL, and Caspase-7-cleavedD198. Each is linked with NUDCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NUDCD1-to-partner and partner-to-NUDCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by NUDCD1-low versus NUDCD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NUDCD1→partner) and Y-score (partner→NUDCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.141	+1.678	.009	.023	3	2
UCEC	VHL →	-1.120	-2.415	<.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.662	+2.926	.003	<.001	3	2
UCEC	eEF2 →	+0.307	+3.169	.025	.018	3	1
UCEC	ERK2 →	+0.168	+1.678	.023	.023	3	1
UCEC	GAPDH →	+0.473	+2.087	.021	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by NUDCD1 expression — UCEC

Explore this box plot interactively →